Boron Nitride Nanotubes as T2 -Weighted MRI Contrast Agents

TitleBoron Nitride Nanotubes as T2 -Weighted MRI Contrast Agents
Publication TypeJournal Article
Year of Publication2010
AuthorsCalucci, L, Ciofani, G, De Marchi, D, Forte, C, Menciassi, A, Menichetti, L, Positano, V
JournalThe Journal of Physical Chemistry Letters
Date Publishedsep

Boron nitride nanotubes (BNNTs) showing superparamagnetic properties due to the presence of Fe nanoparticles attached to one end as residues of the solid-state preparation procedure were tested as potential T2 contrast agents for proton MRI. Measurements of longitudinal and transverse relaxation times of water protons in homogeneous aqueous dispersions of BNNTs wrapped with poly(l-lysine) at different concentrations allowed longitudinal (r1) and transverse (r2) relaxivities to be determined at magnetic field strengths of 1.5 and 7.05 T. The r2 value was higher than those of commercial superparamagnetic iron oxide nanoparticles at 1.5 T and considerably increased at the higher magnetic field investigated. On the basis of the obtained results, Fe-containing BNNTs have the potential to be more powerful T2 contrast-enhancement agents than the currently used ones.